Calculate the distance to the median (DM) adjusted CV2 for a given RangedSummarizedExperiment object. Inspired by the method outlined in Kolodziejczyk et al., 2015, Cell Stem Cell.

Calculate the distance to the median (DM) adjusted CV2 for a given RangedSummarizedExperiment object. Inspired by the method outlined in Kolodziejczyk et al., 2015, Cell Stem Cell.

Usage

DMadjustedCV(object, inputAssay = "TPM", prefix = "")

Arguments

object

A RangedSummarizedExperiment object.

inputAssay

The name of the assay to use for the calculation.

prefix

The prefix to use for the output columns.

Value

A RangedSummarizedExperiment object with the adjusted CV2 in the metadata columns.